Fibromyalgia is a medical condition that affects the muscles and soft tissues all over the body. Frequently misdiagnosed as arthritis, this condition has symptoms that make its diagnosis difficult.
As per latest research, fibromyalgia affects women twice as regularly as men. Some interesting research shows that men produce serotonin about 50 percent faster than women, which is why fibromyalgia syndrome is more common in women.
The cause of this disorder is unknown. As per “central sensitization” hypothesis, individuals with fibromyalgia have a lower limit for pain due to expanded reactivity of agony delicate nerve cells in the spinal cord or brain. Neuropathic nuisance and significant depressive disorder regularly co-happen with fibromyalgia “ the explanation behind this comorbidity is because of shared hereditary variations from the norm, which prompts impairments in monoaminergic, glutamatergic, neurotrophic, opioid and proinflammatory cytokine signaling.
In these susceptible people, mental anxiety or disease can bring about variations from the norm in inflammatory and stress pathways, which control mood and pain. In the end, a refinement and kindling effect happen in specific neurons, prompting the foundation of fibromyalgia and at times a mood disorder. The evidence proposes that the pain in fibromyalgia comes basically from pain processing pathways functioning peculiarly. In direct terms, it can be portrayed as the volume of neurons being set too high. This hyper-edginess of pain processing pathways and under the action of inhibitory pain pathways in the cerebrum brings about pain in the affected individual.
Some neurochemical variations that happen in fibromyalgia control the state of mind, sleep, and energy, consequently clarifying why temperament, sleep, and weariness issues are ordinarily co-morbid with fibromyalgia.
Research has additionally exhibited that fibromyalgia is possibly connected with polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems. However, these polymorphisms are not particular for fibromyalgia and are related with an assortment of allied disorders like constant weakness syndrome and irritable bowel syndrome.
Individuals with 5-HT2A receptor 102T/C polymorphism have been found to be at an increased risk of developing fibromyalgia. Lifestyle is an important precipitating factor for developing fibromyalgia. It is habitually comorbid with stress-related disorders such as chronic fatigue syndrome, post-traumatic stretch issue, and depression. A review discovered a critical relationship amongst fibromyalgia and physical and sexual abuse in both adolescence and adulthood, in spite of the fact that the nature of studies was poor.
Poor lifestyle including smoking, obesity, and absence of physical action may expand the danger of an individual developing fibromyalgia. A detailed scrutiny observed mental injury to be related to fibromyalgia, although not as strongly as in chronic fatigue syndrome. Sleep disturbances and psychological factors are also related to fibromyalgia.
Another theory claims that fibromyalgia is brought on by biochemical changes in the body and might be related to hormonal changes or menopause. Few (though not all) individuals with fibromyalgia have low levels of human development hormone, which may add to muscle pain.
Chronic migraine is a condition where the affected person experiences at least 15 headache days a month. It is observed that at least 8 out of these 15 days are migraine headaches with severe symptoms, and this pattern of discomfort remains consistent for 3 months. Initially, it may not be a frequently occurring episode, however, with time, the episodes may get regular with chronic headaches. If left untreated, this condition can affect a person’s life.
Causes
Several factors determine the onset of this kind of migraine. One of them includes a steady increase in the frequency of episodic headaches. Over-the-counter treatment options that are used to treat frequent headaches stop affecting over time, leading to side effects that develop into chronic headaches. Some other factors that can put an individual at a high risk of developing this condition include mood disorders like anxiety or depression, snoring, excessive caffeine intake, ongoing disturbed sleep patterns, and a history of stressful life events causing emotional or physical trauma. An unhealthy lifestyle leading to an increase in the body mass index (BMI) can also be a causal factor.
Symptoms
There is no difference between symptoms of chronic migraines and episodic migraines. However, the only thing to notice is the increased frequency of episodic headaches in a month. Some typical symptoms of this illness can be observed for timely diagnosis and treatment.
Transitioning symptoms (episodic to chronic migraines)
Diagnosis
A health professional will take a look at the affected person’s health history. If needed, the doctor may ask questions that help understand the migraine patterns. The questions include how and when the migraines begin, how long they last, are there any notable physical factors or triggers that worsen the condition, and where the location of the pain is.
The professional may also ask for a detailed history of other health conditions like anxiety, depression, lifestyle choices that may trigger these headaches, any treatment options used, and possible side effects that could be factored into the diagnosis. Based on the results, appropriate treatment methods will be advised and implemented.
Treatment options
Most of the treatment methods focus on managing the symptoms, the migraine attacks, and reducing the episodes and pain.
One of the treatment therapies includes focusing on lifestyle changes.
Some other treatment options for managing migraine attacks include:
Other techniques include:
Also, maintain a headache diary and note down the possible triggers and the number of migraine attacks in a month. If there’s a notable increase in the attacks, consult a doctor at the earliest. Knowing the triggers can help the doctor chalk out an effective treatment plan.
Preventive treatments and methods
Apart from treatment options that help manage the symptoms, there are preventive treatment methods that reduce the episodes of these headaches to a certain extent. These include using beta blockers and other therapies. One such treatment method also includes using an Allergan product named BOTOX®, which doctors recommend for those 18 years and older. The intravenous treatment method is administered around the neck or the head, where the migraine pain usually affects the person. This ten-minute procedure is not painful and can prevent headaches for three months. The procedure takes place in a doctor’s clinic under close supervision.
Chronic migraine can be painful and disrupt everyday life activities, so choosing the right treatment plan is crucial. Get all the information from a licensed health professional and seek the best possible treatment plan according to a detailed diagnosis.
Melanoma is a type of skin cancer that develops in the cells that produce melanin. The pigment melanin is responsible for giving the skin its color. Advanced melanoma can form inside one’s nose, throat, or digestive tract. Studies show that the risk of melanoma increases in people under 40, especially women. Knowing the early signs of the disease is crucial since melanoma can be treated successfully if detected early.
Stages
There are five stages of melanoma. The cancer cells of Stage 0 melanoma are restricted to the epidermis, the top layer of skin. The epidermis and dermis, the deeper layer of the skin, both contain cancer cells in Stage I melanoma. Stage II melanoma is marked by tumor thickness and ulceration, while Stage III is marked by melanoma deposits in the skin and cancer spreading to nearby lymph nodes. The advanced stage of melanoma, also called metastatic skin cancer, shows the further spread of cancer to distant areas of the body.
Causes of advanced melanoma
The exact cause of melanoma is unknown, although exposure to harsh ultraviolet (UV) radiation, tanning beds, or lamps has been shown to increase one’s risk of getting the disease. One can develop skin disease anywhere in one’s body. Those with a family history of the disease or exposure to radiation or vinyl chloride are also vulnerable to metastatic melanoma.
Signs of advanced melanoma
An early sign of melanoma is the development of an unusual mole. Normal moles are minor and uniform in size and color. But melanoma moles have irregular shapes or borders and can be larger than 6 millimeters. If a mole grows in size, color, and shape and causes itchiness, it’s best to get it checked. Advanced melanoma may lead to chronic fatigue, swollen lymph nodes or liver, loss of appetite, jaundice, skin itchiness, headaches, and even seizures. Depending on where the metastatic melanoma has spread, one may experience chest pain, breathing issues, aching bones, paralysis, sleepiness, and swelling in one’s legs or abdomen.
Melanoma treatment options
The American Cancer Society reports that the five-year survival rate for patients with melanoma that has spread to surrounding lymph nodes is 66%. Surgery is a common way to treat it. Targeted therapy is another method to eliminate the tumor and its metastases selectively. Alternatively, immunotherapy aids a person’s immune system in recognizing and shrinking cancer cells. Other treatments for metastatic skin cancer include chemotherapy and radiation therapy.
Conclusion
Opdulag is a standard treatment for advanced melanoma skin cancer. The therapy, given by intravenous (IV) infusions, works with one’s immune system and is used to fight cancer that has spread or cannot be surgically removed. If one experiences any early signs of melanoma skin cancer, it’s recommended to consult a doctor immediately.