Bladder cancer is considered as the most common types of cancer and is likely to affect men more than women. Recently, the Food and Drug Administration (FDA) approved the use of Nivolumab for the treatment of patients who have bladder cancer. The combination of Nivolumab and Ipilimumab was evaluated in an appearance I clinical trial. In a recent research, 41 patients were treated with a Nivolumab 1mg/kg plus Ipilimumab 3mg/kg dose, out of which doctors got few positive and good results.
Nivolumab is used for the treatment of metastatic bladder cancer among patients whose disease has gotten worse. The FDA approval given to use Nivolumab for the treatment of metastatic bladder cancer was on the basis of the results of Nivolumab clinical trial, which gave positive results. Nivolumab clinical trial was done on 270 patients who were suffering from advanced or metastatic bladder cancer that had worsened over time. 19% of these patients who received Nivolumab had tumor shrinkage for a median of 10.3 months. Out of 53 patients who had tumor shrinkage, 7 patients had complete tumor shrinkage and 46 patients who had partial tumor shrinkage.
Nivolumab functions by releasing a protein called Pd-1 on cancer-fighting immune cells called T cells. Once Nivolumab releases PD-1 protein, T cells can destroy the cancer cells.
Implications of Nivolumab
As there were few options available for treatment of metastatic bladder cancer, doctors started using Nivolumab soon after Nivolumab clinical trial results were approved by FDA. In contrast to typical short-lived responses with cancer therapy in solid metastatic tumors, many responses induced by Nivolumab appear persistent. These persistent results only increased the use of Nivolumab for people who have metastatic bladder cancer.
Note of caution
If a patient is or was on some prescribed drug or has used some herbal products, then he/she must tell this to the doctor before using Nivolumab. Although Nivolumab clinical trial results are positive and FDA-approved, there are many drugs and over-the-counter medicines, which can interact with Nivolumab and deteriorate the situation.
Many people switch to sugar-free gum from the regular variety, thinking it has no harmful health effects. Some do so because of ongoing health complications like diabetes. While it is true that chewing sugar-free gum may have specific benefits and could help one improve their overall well-being, it also has significant downsides. Below are a few important things one should know before heading to the store and buying a pack.
Ingredients in sugar-free gum
Many brands manufacture sugar-free gum, each using different ingredients to give their product a distinct taste and set it apart. While they do not use sugar, they use substitutes that mimic the taste of sugar. Some of these substitutes are artificial sweeteners, while others are derived from natural sources. Let’s look at a few examples:
Besides the above, sugar-free gum may contain chemical and natural ingredients that help provide texture, long-lasting taste, and chewiness. The ingredients usually differ with each brand.
Benefits of sugar-free gum
Here are three probable benefits one might enjoy from chewing sugar-free gum instead of the regular type:
Reduced tooth decay
Studies show that chewing sugar-free gum for a short while after meals may help reduce tooth decay. This is perhaps because chewing causes the mouth to produce more saliva, which washes away microscopic food particles that remain behind and fuel bacteria. Experts reveal that chewing sugar-free gum may also prevent or reduce plaque formation.
Stronger tooth enamel and reduced sensitivity
Since salvia has phosphate and calcium content, it could strengthen tooth enamel. Furthermore, chewing sugar-free gum could help curb teeth sensitivity, which often results from in-office tooth whitening procedures.
Improved memory
Studies indicate that chewing gum, including sugar-free varieties, while performing tasks could improve various aspects of brain function, such as memory, alertness, decision-making, and understanding. Experts also suggest those who chew gum for longer may benefit from reduced signs of stress, anxiety, and depression. While the exact cause of these benefits is yet to be determined, studies point toward better blood flow to the brain caused by chewing.
Besides providing the benefits listed above, sugar-free chewing gum can help avoid conditions like dry mouth (xerostomia). However, one should chew gum as a remedy only if they receive the go-ahead from their healthcare provider.
Disadvantages
Any product consumed in excess may have adverse effects on the body, including sugar-free gum. Chewing it may cause:
Headaches and allergies
Sugar-free gum contains aspartame, a highly debated ingredient among experts. While used as an alternative to sugar, aspartame contains a chemical carcinogen that could increase the risk of headaches. Some may develop hives on the body or suffer from gastrointestinal or respiratory issues if allergic to the ingredient. Therefore, one should speak to an expert before chewing sugar-free gum that contains aspartame.
Gastrointestinal problems
Some manufacturers use sorbitol in their sugar-free gum. When a person consumes too much of the ingredient, it may lead to gastrointestinal symptoms like abdominal cramps, bloating, and gas. Too much sorbitol may also trigger diarrhea in some people.
Jaw disorders
Chewing gum all the time, including sugar-free options, could cause the jaw muscles to tighten. As a result, one may experience jaw pain. Chewing gum regularly has also been associated with increased temporomandibular joint pain (TMJ). Those with this disorder may experience chronic symptoms like soreness, discomfort, and headaches.
Dental device damage
Chewing gum of any kind may have adverse effects on dental devices. The product could damage implants, which could hamper one’s oral health and also be quite expensive to fix.
Besides increasing the risk of the problems listed above, sugar-free chewing gum can lead to cancerous developments in the body and an unusual increase in appetite. People with a rare hereditary disorder called phenylketonuria are especially advised to limit their consumption of phenylalanine (a component of aspartame) as their bodies cannot metabolize it.
Tips to reduce gum-related problems
Learning about the benefits and downsides of sugar-free gum can help one make better decisions for their well-being. Here are a few tips to reduce the risk of health problems from chewing gum:
Following these guidelines will help minimize the harmful effects of chewing gum. One should speak to a health expert if they have any questions regarding any ingredient used in the product.
Tooth enamel is the strong outer layer that protects the teeth from damage and decay. Over time, the enamel gets damaged by factors such as poor oral hygiene, acidic foods, and tooth erosion. Enamel repair is a vital process that restores this outer layer’s strength and integrity. It is crucial for individuals to understand the details of enamel repair, its importance, and treatment options, and be aware of practical tips for healthy enamel.
The significance of enamel repair
Enamel repair is vital for maintaining dental health and preventing tooth damage. Tooth enamel is the hardest substance in the human body, but it can deteriorate from repeated acid attacks by bacteria, plaque, and food habits. When the enamel wears away or gets damaged, the underlying dentin becomes exposed, causing tooth sensitivity, pain, and an increased risk of cavities.
Enamel restoration is crucial for preserving the teeth’s structural integrity and bypassing the need for more invasive dental treatments. Enamel repair protects the teeth from acid erosion, strengthens the enamel surface, and reduces tooth sensitivity. When enamel damage is promptly addressed, individuals can maintain healthy teeth and prevent the onset of oral health complications.
Understanding enamel demineralization
The initial stage of enamel damage is termed enamel demineralization and it occurs when acids dissolve the enamel’s mineral content. This is often triggered by the consumption of acidic foods and beverages, poor oral hygiene, and certain health conditions. Demineralization weakens the enamel, making it vulnerable to further damage.
Various preventive measures can be adopted to mitigate enamel demineralization. For one, regular brushing and flossing destroy plaque and bacteria, reducing acid production. The use of fluoride toothpaste and mouth rinses can also support enamel remineralization by replenishing the lost minerals. Dentists may also recommend dental sealants or thin protective coatings applied to the teeth, which thwart acid attacks.
Enamel repair treatment options
When enamel damage advances beyond the demineralization stage, enamel repair treatment is the only viable option. The treatment choice depends on the extent of the damage and an individual’s specific needs. Some common enamel repair options include:
Dental bonding
This procedure involves applying a tooth-colored resin material to the damaged enamel, which is then shaped and polished to match the natural tooth. Dental bonding helps restore the appearance and functionality of the tooth while protecting it from further damage.
Dental veneers
These are thin shells made of porcelain or composite resin that are bonded to the teeth’s front surface. They can be used to repair enamel damage, correct tooth discoloration, and enhance an individual’s overall appearance when they smile.
Dental crowns
These may be recommended when the enamel damage or decay is extensive. Crowns are tooth-shaped caps that cover the entire visible portion of the teeth, and help restore their strength, shape, and appearance.
Enamel microabrasion
This minimally invasive procedure involves the removal of a thin layer of enamel using an abrasive substance. Enamel microabrasion is commonly used to treat superficial enamel stains and defects, restoring the teeth’s natural appearance.
Remineralization treatments
Remineralizing agents such as fluoride varnishes and gels can be applied to the teeth to enhance the remineralization process and strengthen the enamel.
Things to remember
Enamel repair is a vital aspect for maintaining optimal dental health. By understanding the significance of enamel repair and exploring the treatment options available, individuals can take proactive steps to address enamel damage and preserve their oral well-being.
Remember, practicing good oral hygiene, including regular brushing and flossing, combined with routine dental check-ups, is essential for preventing enamel damage and maintaining a healthy smile. Additionally, adopting a tooth-friendly meal plan, reducing the consumption of acidic foods and beverages, and avoiding harmful habits such as teeth grinding can significantly contribute to enamel preservation.
Besides professional treatment, you can also adopt certain lifestyle practices that can aid in enamel repair. Avoiding excessive consumption of sugary and acidic foods and beverages, limiting the intake of carbonated drinks, and using a straw when consuming acidic beverages can help minimize enamel erosion.
If you suspect enamel damage or experience tooth sensitivity, promptly consult a dental professional. They will assess your condition, recommend appropriate treatment options, and guide you on preventive measures to protect your enamel.
Taking proactive steps to repair enamel damage enhances the strength and appearance of your teeth, besides safeguarding them from impending oral health issues. Enamel repair is an investment for your long-term dental health and oral well-being.
Furthermore, incorporating foods rich in calcium, including dairy products and leafy greens, can provide essential nutrients for remineralizing and strengthening the enamel. Drinking fluoridated water or using fluoride supplements as recommended by your dental professional can also contribute to enamel repair.
Conclusion
Protecting tooth enamel is a lifelong commitment that pays off in terms of improved dental health and a brighter, more confident smile. Hence, take charge of your oral health, embrace enamel repair, and let your smile shine with vitality and beauty! Your teeth deserve the best care to ensure a lifetime of dental well-being.